Publications

2024

Andrée L, Egberink RO, Heesakkers R, Suurmond CE, Joziasse LS, Khalifeh M, Wang R, Yang F, Brock R, Leeuwenburgh SCG. Local mRNA Delivery from Nanocomposites Made of Gelatin and Hydroxyapatite Nanoparticles. ACS Appl Mater Interfaces. 2024 Sep 25;16(38):50497-50506. doi: 10.1021/acsami.4c12721.

Alves Pereira MM, Piazza R, Santana AP, Ricardo Barão VA, Malheiros SS, van den Beucken JJJP, de Molon RS, de Avila ED. Unraveling the Applicability of LbL Coatings for Drug Delivery in Dental Implant-Related Infection Treatment. ACS Biomater Sci Eng. 2024 Nov 30. doi: 10.1021/acsbiomaterials.4c01037.

Han J, Sanders JGF, Andrée L, van Oirschot BAJA, Plachokova AS, van den Beucken JJJP, Leeuwenburgh SCG, Yang F. Development of Zinc-Containing Chitosan/Gelatin Coatings with Immunomodulatory Effect for Soft Tissue Sealing around Dental Implants. Tissue Eng Regen Med. 2024 Nov 23. doi: 10.1007/s13770-024-00680-y.

Wang Z, Kregel M, Meijers JL, Franch J, Cuijpers VMJI, Ahlers D, Karst U, Slootweg P, van der Geest IC, Leeuwenburgh SC, van den Beucken JJ. Cisplatin-functionalized dual-functional bone substitute granules for bone defect treatment after bone tumor resection. Acta Biomater. 2024 Nov 17:S1742-7061(24)00675-5. doi: 10.1016/j.actbio.2024.11.020.

van den Beucken J, De Laporte L. Editorial for Special Issue to Honor Prof. James Kirkpatrick. Tissue Eng Part C Methods. 2024 Sep;30(9):366-367. doi: 10.1089/ten.TEC.2024.0262.

de Silva L, van den Beucken JJJP, Rosenberg AJWP, Longoni A, Gawlitta D. Unraveling devitalization: its impact on immune response and ectopic bone remodeling from autologous and allogeneic callus mimics. Stem Cells Transl Med. 2024 Sep 14:szae063. doi: 10.1093/stcltm/szae063.

Xiang Q, Li L, Ji W, Gawlitta D, Walboomers XF, van den Beucken JJJP. Beyond resorption: osteoclasts as drivers of bone formation. Cell Regen. 2024 Oct 11;13(1):22. doi: 10.1186/s13619-024-00205-x.

Andrée L, Joziasse LS, Adjobo-Hermans MJW, Yang F, Wang R, Leeuwenburgh SCG. Effect of Hydroxyapatite Nanoparticle Crystallinity and Colloidal Stability on Cytotoxicity. ACS Biomater Sci Eng. 2024 Oct 7. Online ahead of print. doi: 10.1021/acsbiomaterials.4c01283.

Andrée L, Egberink RO, Heesakkers R, Suurmond CE, Joziasse LS, Khalifeh M, Wang R, Yang F, Brock R, Leeuwenburgh SCG. Local mRNA Delivery from Nanocomposites Made of Gelatin and Hydroxyapatite Nanoparticles. ACS Appl Mater Interfaces 2024 Sep 25;16(38):50497-50506. doi: 10.1021/acsami.4c12721.

Cuypers LAB, de Boer L, Wang R, Walboomers XF, Yang F, Zaat SAJ, Leeuwenburgh SCG. Antibacterial Activity of Zinc-Doped Hydroxyapatite and Vancomycin-Loaded Gelatin Nanoparticles against Intracellular Staphylococcus aureus in Human THP-1 Derived Macrophages. ACS Appl Nano Mater. 2024 Sep 11;7(18):21964-21974. doi: 10.1021/acsanm.4c03941.

Wu, D.J., Rutten, M.G., Huang, J., Schotman, M.J., van Sprang, J.F., Tiemeijer, B.M., Ter Huurne, G.M., Wijnands, S.P., Diba, M. and Dankers, P.Y. Tuning structural organization via molecular design and hierarchical assembly to develop supramolecular thermoresponsive hydrogels. Macromolecules 2024, 54, 6606-6615. https://doi.org/10.1021/acs.macromol.4c00567.

van Erk M, Félix Lanao R, Calon N, Tropper J, Leeuwenburgh SCG, van Goor H. Cellular viability of fibroblasts, osteoblasts and osteoclasts in response to bone adhesive alendronate-functionalized poly(2-oxazoline). Polymer Testing 2024, 131, 108344. doi.org/10.1016/j.polymertesting.2024.108344.

Yuan L, Wei J, Xiao S, Jin S, Xia X, Liu H, Liu J, Hu J, Zuo Y, Li Y, Yang F, Li J. Nano-laponite encapsulated coaxial fiber scaffold promotes endochondral osteogenesis. Regen Biomater. 2024 Jul 4;11:rbae080. doi: 10.1093/rb/rbae080.

Verstappen K, Klymov A, Cicuéndez M, da Silva DM, Barroca N, Fernández-San-Argimiro FJ, Madarieta I, Casarrubios L, Feito MJ, Diez-Orejas R, Ferreira R, Leeuwenburgh SCG, Portolés MT, Marques PAAP, Walboomers XF. Biocompatible adipose extracellular matrix and reduced graphene oxide nanocomposite for tissue engineering applications. Mater Today Bio. 2024 Apr 17;26:101059. doi: 10.1016/j.mtbio.2024.101059.

Maciel MM, Hassani Besheli N, Correia TR, Mano JF, Leeuwenburgh SCG. Encapsulation of pristine and silica-coated human adipose-derived mesenchymal stem cells in gelatin colloidal hydrogels for tissue engineering and bioprinting applications. Biotechnol J. 2024 Feb;19(2):e2300469. doi: 10.1002/biot.202300469.

Koons GL, Kontoyiannis PD, Diaz-Gomez L, Elsarrag SZ, Scott DW, Diba M, Mikos AG. Influence of polymeric microparticle size and loading concentration on 3D printing accuracy and degradation behavior of composite scaffolds. 3D Print Addit Manuf. 2024 Apr 1;11(2). doi: 10.1089/3dp.2022.0208.

Han J, Leeuwenburgh SCG, Jansen JA, Yang F, van Oirschot BAJA. Biological Processes in Gingival Tissue Integration Around Dental Implants. Tissue Eng Part B Rev. 2024 Apr 10. doi: 10.1089/ten.TEB.2023.0371.

Han J, Andrée L, Deng D, van Oirschot BAJA, Plachokova AS, Leeuwenburgh SCG, Yang F. Biofunctionalization of dental abutments by a zinc/chitosan/gelatin coating to optimize fibroblast behavior and antibacterial properties. J Biomed Mater Res A. 2024 May 9. J Biomed Mater Res A. 2024 May 9.

Suurmond CE, Leeuwenburgh SCG, van den Beucken JJJP. Modelling bone metastasis in spheroids to study cancer progression and screen cisplatin efficacy. Cell Prolif. 2024 Jun 20:e13693. doi: 10.1111/cpr.13693

Lei X, Yang B, Chen J, Yang F, Tang J, Li J, Zhao Q, Zhang J, Li J, Li Y, Zuo Y Biodegradable Polyurethane Scaffolds in Regeneration Therapy: Characterization and In Vivo Real-Time Degradation Monitoring by Grafted Fluorescent Tracer ACS Appl Mater Interfaces. 2024 Jan 10;16(1):111-126 doi: 10.1021/acsami.3c13187 

Govindaraj K, Meteling M, van Rooij J, Becker M, van Wijnen AJ, van den Beucken JJJP, Ramos YFM, van Meurs J, Post JN, Leijten J. Osmolarity-Induced Altered Intracellular Molecular Crowding Drives Osteoarthritis Pathology. Adv Sci (Weinh). 2024 Jan 11:e2306722. doi: 10.1002/advs.202306722. 

Wang Z, Geest ICV, Leeuwenburgh SC, van den Beucken JJ Bifunctional bone substitute materials for bone defect treatment after bone tumor resection Mater Today Bio. 2023 Dec 1;23:100889. doi: 10.1016/j.mtbio.2023.100889.  

Hassani Besheli N, Martens M, Macías-Sánchez E, Olijve J, Yang F, Sommerdijk N, Leeuwenburgh SCG Unraveling the Formation of Gelatin Nanospheres by Means of Desolvation Nano Lett. 2023 Dec 13;23(23):11091-11098. Nano Lett. 2023 Dec 13;23(23):11091-11098.

2023

Hogan KJ, Perez MR, Öztatlı H, Si S, Wang Z, Jiang EY, Diba M, Garipcan B, Mikos AG. Development of 3D-printing composite inks based on photoreactive cartilage extracellular matrix and gelatin nanoparticles. Bioprinting, Volume 36, e00317. doi: 10.1016/j.bprint.2023.e00317

Cuypers LAB, Bertsch P, Wang R, Harhangi HR, Joziasse LS, Walboomers XF, van Niftrik L, Yang F, Leeuwenburgh SCG. The effect of zinc doping on the cytocompatibility and antibacterial efficacy of hydroxyapatite nanoparticles for treatment of bone infection. Open Ceramics, 2023;16:100488. doi: 10.1016/j.oceram.2023.100488.

De Laporte L, van den Beucken J. Call for Special Issue Papers: Special Issue for Prof. James Kirkpatrick in Honor of His Achievements in Tissue Engineering/Regenerative Medicine Tissue Eng Part A. 2023 Dec;29(23-24):605-606. doi: 10.1089/ten.tea.2023.29050.cfp.

De Laporte L, van den Beucken J. Call for Special Issue Papers: Special Issue for Prof. James Kirkpatrick in Honor of His Achievements in Tissue Engineering/Regenerative Medicine Tissue Eng Part B Rev. 2023 Dec;29(6):589-590. doi: 10.1089/ten.teb.2023.29021.cfp. 

De Laporte L, van den Beucken J. Call for Special Issue Papers: Special Issue for Prof. James Kirkpatrick in Honor of His Achievements in Tissue Engineering/Regenerative Medicine Tissue Eng Part C Methods. 2023 Dec;29(12):545-546. doi: 10.1089/ten.tec.2023.29041.cfp. 

Madariaga VI, Pereira-Cenci T, Walboomers XF, Loomans BAC. Association between salivary characteristics and tooth wear: A systematic review and meta-analysis. J Dent. 2023 Nov;138:104692. doi: 10.1016/j.jdent.2023.104692.

Abdullah Faqeer, Mengzhen Wang, Gulzar Alam, Arshad Ahmed Padhiar, Dexiu Zheng, Zhiming Luo, Irene Shuping Zhao, Guangqian Zhou, Jeroen JJP. van den Beucken, Huanan Wang, Yang Zhang. Cleaved SPP1-rich extracellular vesicles from osteoclasts promote bone regeneration via TGFβ1/SMAD3 signaling. Biomaterials in press. doi: 10.1016/j.biomaterials.2023.122367

Katie J Hogan, Hayriye Öztatlı, Marissa Perez, Sophia Si, Reyhan Umurhan, Elysa Jui, Ziwen Wang, Emily Jiang, Sa Han, Mani Diba, K Jane Grande-Allen, Bora Garipcan, Antonios G Mikos. Development of Photoreactive Demineralized Bone Matrix 3D-Printing Colloidal Inks for Bone Tissue Engineering. Regenerative Biomaterials. doi: 10.1093/rb/rbad090.

LAB Cuypers, P Bertsch, R Wang, HR Harhangi, LS Joziasse, XF Walboomers, L van Niftrik, F Yang, SCG Leeuwenburgh. The effect of zinc doping on the cytocompatibility and antibacterial efficacy of hydroxyapatite nanoparticles for treatment of bone infection. Open Ceramics. doi: 10.1016/j.oceram.2023.100488

Ning K, Yang F, Bronkhorst E, Ruben J, Nogueira L, Haugen H, Loomans B, Leeuwenburgh S. Fatigue behaviour of a self-healing dental composite. Dent Mater. 2023;39(10):913-921. doi: 10.1016/j.dental.2023.08.172

Ning K, Bronkhorst E, Crins L, van der Meer W, Pereira-Cenci T, Yang F, Leeuwenburgh S, Loomans B. Wear behaviour of direct composite restorations in tooth wear patients: a 5-year clinical study. J Dent. 2022;127:104354. doi 10.1016/j.jdent.2022.104354.

Robin H.M. van der Meijden, Deniz Daviran, Luco Rutten, X. Frank Walboomers, Elena Macías-Sánchez, Nico Sommerdijk, Anat Akiva. A 3D Cell-Free Bone Model Shows Collagen Mineralization is Driven and Controlled by the Matrix. Adv. Funct. Mater.2023, 2212339. https://doi.org/10.1002/adfm.202212339.

Op 't Veld RC, Joosten L, Laverman P, Bronkhorst EM, Jansen JA, Walboomers XF, Wagener FADTG. Repeated Application and Removal of Polyisocyanopeptide Hydrogel Wound Dressings in a Splinted Full-Thickness Wound Model. Int J Mol Sci. 2023 Mar 7;24(6):5127. doi: 10.3390/ijms24065127.

Oirschot BV, van den Beucken JJJP, Mikos AG, Jansen JA. Lateral Bone Augmentation Using a Three-Dimensional-Printed Polymeric Chamber to Compare Biomaterials. Tissue Eng Part C Methods. 2023 May 24. doi: 10.1089/ten.TEC.2023.0025.

Andrée L, Bertsch P, Wang R, Becker M, Leijten J, Fischer P, Yang F, Leeuwenburgh SCG. A Modular Platform for Cytocompatible Hydrogels with Tailored Mechanical Properties Based on Monolithic Matrices and Particulate Building Blocks. Biomacromolecules. 2023 Jun 12;24(6):2755-2765. doi: 10.1021/acs.biomac.3c00177.

Andrée L, Dodemont J, Harhangi HR, Dijkstra K, van Niftrik L, Yang F, Leeuwenburgh SCG. Inactivation of Staphylococcus aureus in gelatin nanoparticles using supercritical carbon dioxide. J Supercritical Fluids 2023;200:105979. doi.org/10.1016/j.supflu.2023.105979.

Cheng, X., Liu, Y., Liu, O., Lu, Y., Liao, Z., Hadzhieva, Z., Chen, L., Leeuwenburgh, S.G., Boccaccini, A.R. and Yang, F. Electrophoretic deposition of coatings for local delivery of therapeutic agents. Progress in Materials Science. 2023 Mar 14:101111. doi: 10.1016/j.pmatsci.2023.101111

Huang C, Sanaei F, Verdurmen WPR, Yang F, Ji W, Walboomers XF. The Application of Organs-on-a-Chip in Dental, Oral, and Craniofacial Research. J Dent Res. 2023 Apr;102(4):364-375. doi: 10.1177/00220345221145555

Hassani Besheli N, Verbakel J, Hosseini M, Andrée L, Joosten B, Walboomers XF, Cambi A, Yang F, Leeuwenburgh SCG. Cellular Uptake of Modified Mesoporous Bioactive Glass Nanoparticles for Effective Intracellular Delivery of Therapeutic Agents. Int J Nanomedicine. 2023 Mar 28;18:1599-1612. doi: 10.2147/IJN.S397297.

HB Bingol, JCME Bender, JA Opsteen, SCG Leeuwenburgh. Bone adhesive materials: From bench to bedside. Materials Today Bio. 2023;19:100599. 10.1016/j.mtbio.2023.100599

Hosseini M, Hassani Besheli N, Deng D, Lievens C, Zuo Y, Leeuwenburgh SCG, Yang F. Facile post modification synthesis of copper-doped mesoporous bioactive glass with high antibacterial performance to fight bone infection. Biomater Adv. 2023 Jan;144:213198. doi: 10.1016/j.bioadv.2022.213198

Husch JFA, Coquelin L, Chevallier N, Tiemessen D, Oosterwijk E, van Rheden R, Woud C, Vossen J, Leeuwenburgh SCG, van den Beucken JJJP. Comparison of osteogenic capacity and osteoinduction of adipose tissue-derived cell populations. Tissue Eng Part C. 2023. doi: 10.1089/ten.TEC.2023.0039.

Camargo WA, Hoekstra JW, Jansen JA, van den Beucken JJJP. Influence of Bisphosphonate Treatment on Bone Substitute Performance in Osteoporotic Conditions. Clin Impl Dent and Rel Res 2023.

Liu Q, Lodoso-Torrecilla I, Klein Gunnewiek R, Harhangi HR, Mikos AG, van Niftrik L, Jansen JA, Chen L, van den Beucken JJJP. Tunable calcium phosphate cement formulations for predictable local release of doxycycline. Materialia 2023. doi: 10.1016/j.mtla.2023.101769

Watson E, Pearce HA, Hogan KJ, van Dijk NWM, Smoak MM, Barrios S, Smith BT, Tatara AM, Woernley TC, Shum J, Pearl CB, Melville JC, Ho T, Hanna IA, Demian N, van den Beucken JJJP, Jansen JA, Wong ME, Mikos AG. Repair of complex ovine segmental mandibulectomy utilizing customized tissue engineered bony flaps. PLoS One. 2023 Feb 24;18(2):e0280481. doi: 10.1371/journal.pone.0280481.

van Oirschot B, Mikos AG, Liu Q, van den Beucken JJJP, Jansen JA. Fast Degradable Calcium Phosphate Cement for Maxillofacial Bone Regeneration. Tissue Eng Part A. 2023 Mar;29(5-6):161-171. doi: 10.1089/ten.TEA.2022.0177.

Op 't Veld RC, Joosten L, Laverman P, Bronkhorst EM, Jansen JA, Walboomers XF, Wagener FADTG. Repeated Application and Removal of Polyisocyanopeptide Hydrogel Wound Dressings in a Splinted Full-Thickness Wound Model. Int J Mol Sci. 2023 Mar 7;24(6):5127.  doi: 10.3390/ijms24065127

2022

Wu DT, Diba M, Yang S, Freedman BR, Elosegui-Artola A, Mooney DJ. Hydrogel viscoelasticity modulates migration and fusion of mesenchymal stem cell spheroids. Bioeng Transl Med.  doi: 10.1002/btm2.10464

Lemoine P, Acheson J, McKillop S, van den Beucken JJ, Ward J, Boyd A, Meenan BJ. Nanoindentation and nano-scratching of hydroxyapatite coatings for resorbable magnesium alloy bone implant applications. J Mech Behav Biomed Mater. 2022 Sep;133:105306. doi: 10.1016/j.jmbbm.2022.105306.

Cordeiro JM, Barão VAR, de Avila ED, Husch JFA, Yang F, van den Beucken JJJP. Tailoring Cu2+-loaded electrospun membranes with antibacterial ability for guided bone regeneration. Biomater Adv. 2022 Aug;139:212976. doi: 10.1016/j.bioadv.2022.212976.

Zhang Y, van den Beucken JJJP. Special Issue: Immunomodulatory Methods Toward Tissue Regeneration. Tissue Eng Part C Methods. 2022 Aug;28(8):375-376. doi: 10.1089/ten.tec.2022.29034.editorial. 

Bertsch P, Diba M, Mooney DJ, Leeuwenburgh SCG. Self-Healing Injectable Hydrogels for Tissue Regeneration. Chem Rev. 2022 Aug 5. doi: 10.1021/acs.chemrev.2c00179. 

Andree L, Oude Egberink R, Dodemont J, Hassani Besheli N, Yang F, Brock R, Leeuwenburgh SCG. Gelatin Nanoparticles for Complexation and Enhanced Cellular Delivery of mRNA Nanomaterials (accepted)

Celikkin N, Mastrogiacomo S, Dou W, Heerschap A, Oosterwijk E, Walboomers XF, Święszkowski W. In vitro and in vivo assessment of a 3D printable gelatin methacrylate hydrogel for bone regeneration applications. J Biomed Mater Res B Appl Biomater. 2022 Sep;110(9):2133-2145. doi: 10.1002/jbm.b.35067.

Oirschot BV, Zhang Y, Alghamdi HS, Cordeiro JM, Nagay B, Barão VA, de Avila ED, van den Beucken J. Surface engineering for dental implantology: favoring tissue responses along the implant. Tissue Eng Part A. 2022 Mar 30. doi: 10.1089/ten.TEA.2021.0230.

Zhang Y, Polman M, Mohammad AF, Hermens I, Zhuang Z, Wang H, van den Beucken JJ. Species-independent stimulation of osteogenic differentiation induced by osteoclasts. Biochem Biophys Res Commun. 2022 May 28;606:149-155. doi: 10.1016/j.bbrc.2022.03.115. 

Bohner M, Maazouz Y, Ginebra MP, Habibovic P, Schoenecker JG, Seeherman H, van den Beucken JJJP, Witte F. Sustained local ionic homeostatic imbalance caused by calcification modulates inflammation to trigger heterotopic ossification. Acta Biomater. 2022 Apr 6:S1742-7061(22)00197-0. doi: 10.1016/j.actbio.2022.03.057. 

Han J, Hassani Besheli N, Deng D, van Oirschot BAJA, Leeuwenburgh SCG, Yang F. Tailoring Copper-Doped Bioactive Glass/Chitosan Coatings with Angiogenic and Antibacterial Properties. Tissue Eng Part C Methods. 2022 May 10. doi: 10.1089/ten.TEC.2022.0014.

Van Rijt S, de Groot K, Leeuwenburgh SCG. Calcium phosphate and silicate-based nanoparticles: history and emerging trends. Tissue Eng Part A. 2022 Feb 2. doi: 10.1089/ten.TEA.2021.0218.

2021

Paulino da Silva Filho O, Ali M, Nabbefeld R, Primavessy D, Bovee-Geurts PH, Grimm S, Kirchner A, Wiesmüller KH, Schneider M, Walboomers XF, Brock R. A comparison of acyl-moieties for noncovalent functionalization of PLGA and PEG-PLGA nanoparticles with a cell-penetrating peptide. RSC Adv. 2021 Nov 10;11(57):36116-36124. doi: 10.1039/d1ra05871a.

Verstappen K, Aquarius R, Klymov A, Wever KE, Damveld L, Leeuwenburgh SCG, Bartels RHMA, Hooijmans CR, Walboomers XF. Systematic Evaluation of Spinal Cord Injury Animal Models in the Field of Biomaterials. Tissue Eng Part B Rev. 2021 Dec 17. doi: 10.1089/ten.TEB.2021.0194.

Wang Z, Parreiras Nogueira L, Haugen HJ, Van Der Geest ICM, Caetanode Almeida Rodrigues P, Janssen D, Bitter T, van den Beucken JJJP, Leeuwenburgh SCG. Dual-functional porous and cisplatin-loaded polymethylmethacrylate cement for reconstruction of load-bearing bone defect kills bone tumor cells. Bioact Mater 2021 (in press) doi: 10.1016/j.bioactmat.2021.12.023.

Bertsch P, Andrée L, Besheli NH, Leeuwenburgh SCG. Epub ahead of print. Colloidal hydrogels made of gelatin nanoparticles exhibit fast stress relaxation at strains relevant for cell activity. Acta Biomater. 2021 Nov 2:S1742-7061(21)00728-5. doi: 10.1016/j.actbio.2021.10.053. 

Erezuma I, Eufrasio-da-Silva T, Golafshan N, Deo K, Mishra YK, Castilho M, Gaharwar AK, Leeuwenburgh S, Dolatshahi-Pirouz A, Orive G. Nanoclay Reinforced Biomaterials for Mending Musculoskeletal Tissue Disorders. Adv Healthc Mater. 2021 Aug;10(16):e2100217. doi: 10.1002/adhm.202100217. 

Sánchez-Fernández MJ, Peerlings M, Félix Lanao RP, Bender JCME, van Hest JCM, Leeuwenburgh SCG. Bone-adhesive barrier membranes based on alendronate-functionalized poly(2-oxazoline)s. J Mater Chem B. 2021 Jul 28;9(29):5848-5860. doi: 10.1039/d1tb00502b. 

Oliveira CS, Leeuwenburgh S, Mano JF. New insights into the biomimetic design and biomedical applications of bioengineered bone microenvironments. APL Bioeng. 2021 Nov 3;5(4):041507. PMID: 34765857; PMCID: doi: 10.1063/5.0065152. 

Sánchez-Fernández MJ, Rutjes J, Félix Lanao RP, Bender JCME, van Hest JCM, Leeuwenburgh SCG. Bone-Adhesive Hydrogels Based on Dual Crosslinked Poly(2-oxazoline)s. Macromol Biosci. 2021 Sep 27:e2100257. Epub ahead of print. doi: 10.1002/mabi.202100257. 

Palacio-Castañeda V, Oude Egberink R, Sait A, Andrée L, Sala BM, Hassani Besheli N, Oosterwijk E, Nilvebrant J, Leeuwenburgh SCG, Brock R, Verdurmen WPR. Mimicking the Biology of Engineered Protein and mRNA Nanoparticle Delivery Using a Versatile Microfluidic Platform. Pharmaceutics. 2021 Nov 17;13(11):1944. doi: 10.3390/pharmaceutics13111944.  

Long D, Cheng X, Hao Z, Sun J, Umuhoza D, Liu Y, Chen L, Xiang Z, Yang F, Zhao A. Genetic hybridization of highly active exogenous functional proteins into silk-based materials using "light-clothing" strategy Matter 2021 Jun; 4(6):2039-2058 doi: 10.1016/j.matt.2021.03.020 

Ning K, Bronkhorst E, Bremers A, Bronkhorst H, van der Meer W, Yang F, Leeuwenburgh S, Loomans B. Wear behavior of a microhybrid composite vs. a nanocomposite in the treatment of severe tooth wear patients: A 5-year clinical study Dent Mater. 2021 Sep 24:S0109-5641(21)00266-9 doi: 10.1016/j.dental.2021.09.011 

Cordeiro JM, Nagay BE, Dini C, Souza JGS, Rangel EC, da Cruz NC, Yang F, van den Beucken JJJP, Barão VAR Copper source determines chemistry and topography of implant coatings to optimally couple cellular responses and antibacterial activity Mater Sci Eng: C. 2021 Nov; in press doi: 10.1016/j.msec.2021.112550 

Hoekstra JWM, van Oirschot BA, Jansen JA, van den Beucken JJ. Innovative implant design for continuous implant stability: A mechanical and histological experimental study in the iliac crest of goats. J Mech Behav Biomed Mater. 2021 Oct;122:104651. doi: 10.1016/j.jmbbm.2021.104651. 

Husch JFA, Stessuk T, den Breejen C, van den Boom M, Leeuwenburgh SCG, van den Beucken JJJP. A Practical Procedure for the In Vitro Generation of Human Osteoclasts and Their Characterization. Tissue Eng Part C Methods. 2021 Jul;27(7):421-432. doi: 10.1089/ten.TEC.2021.0122. 

van Houdt CIA, Koolen MKE, Lopez-Perez PM, Ulrich DJO, Jansen JA, Leeuwenburgh SCG, Weinans HH, van den Beucken JJJP. Regenerating Critical Size Rat Segmental Bone Defects with a Self-Healing Hybrid Nanocomposite Hydrogel: Effect of Bone Condition and BMP-2 Incorporation. Macromol Biosci. 2021 Aug;21(8):e2100088. doi: 10.1002/mabi.202100088. 

Liu Y, Lim R, Chanchareonsook N, Walboomers XF, Jansen JA, Saffari SE, Goh BT. Third-generation modular mandible endoprosthesis in Macaca fascicularis. Int J Oral Maxillofac Surg. 2020 Nov 30:S0901-5027(20)30372-6. doi: 10.1016/j.ijom.2020.09.020. 

Cheng X, D Long, L Chen, JA Jansen, SCG Leeuwenburgh, F Yang Electrophoretic deposition of silk fibroin coatings with pre-defined architecture to facilitate precise control over drug delivery Bioactive Materials 6 (11), 4243-4254 doi.org/10.1016/j.bioactmat.2021.03.046 

Van Erk M, Van Luijk J, Yang F, Leeuwenburgh SCG, Sánchez-Fernández MJ, Hermans E, Félix Lanao RP, Van Goor H. A Systematic Review and Meta‐Analyses on Animal Models Used in Bone Adhesive Research. J Orthop Res. 2022 Mar;40(3):624-633 doi: 10.1002/jor.25057

Andrée L, Yang F, Brock R, Leeuwenburgh SCG Designing biomaterials for the delivery of RNA therapeutics to stimulate bone healing Mater Today Bio. 2021 Mar 6;10:100105 doi: 10.1016/j.mtbio.2021.100105 

Long Y, Cheng X, Jansen JA, Leeuwenburgh SGC, Mao J, Yang F, Chen L The molecular conformation of silk fibroin regulates osteogenic cell behavior by modulating the stability of the adsorbed protein-material interface Bone Res. 2021 Feb 11;9(1):13 doi: 10.1038/s41413-020-00130-0 

Ali M, Yang F, Plachokova AS, Jansen JA, Walboomers XF Application of specialized pro-resolving mediators in periodontitis and peri-implantitis: a review Eur J Oral Sci. 2021 Feb;129(1):e12759 doi: 10.1111/eos.12759 

Stessuk T, Husch J, Hermens IAT, Hofmann S, van den Beucken JJJP Osteogenic differentiation driven by osteoclasts and macrophages J Immun Tiss Regen. 2021 May:12:100044. doi: 10.1016/j.regen.2021.100044 

Guo JL, Kim YS, Koons GL, Lam J, Navara AM, Barrios S, Xie VY, Watson E, Smith BT, Pearce HA, Orchard EA, van den Beucken JJJP, Jansen JA, Wong ME, Mikos AG. Bilayered, Peptide-Biofunctionalized Hydrogels for In Vivo Osteochondral Tissue Repair Acta Biomater. 2021 Apr 27:S1742-7061(21)00282-8. doi: 10.1016/j.actbio.2021.04.038. 

Shaheen MY, Basudan AM, Niazy AA, van den Beucken JJJP, Jansen JA, Alghamdi HS Effect of systemic zoledronic acid dosing regimens on bone regeneration in osteoporotic rats Appl. Sci. 2021, 11(4), 1906 doi: 10.3390/app11041906 

Cerqueira A, Araújo-Gomes N, Zhang Y, van den Beucken JJJP, Martínez-Ramos C, Ozturan S, Izquierdo R, Muriach M, Romero-Cano R, Baliño P, Romero-Gavilán FJ. Evaluation of the inflammatory responses to sol-gel coatings with distinct biocompatibility levels. J Biomed Mater Res A. 2021 Feb 20. doi: 10.1002/jbm.a.37149.

Verza BS, van den Beucken JJJP, Brandt JV, Jafelicci Jr M, Barão VAR, Piazza RD, Tagit O, Spolidorio DMP, Vergani CE, de Avila ED. A long-term controlled drug-delivery with anionic beta cyclodextrin complex in layer-by-layer coating for percutaneous implants devices. Carbohydr Polym. 2021 Apr 1;257:117604. doi: 10.1016/j.carbpol.2020.117604.

Duan R, Zhang Y, van Dijk L, Barbieri D, van den Beucken J, Yuan H, de Bruijn J. Coupling between macrophage phenotype, angiogenesis and bone formation by calcium phosphates. Materials Science & Engineering C 122 (2021) 111948. doi: 10.1016/j.msec.2021.111948.

Barbanente A, Palazzo B, Esposti LD, Adamiano A, Iafisco M, Ditaranto N, Migoni D, Gervaso F, Nadar R, Ivanchenko P, Leeuwenburgh S, Margiotta N. Selenium-doped hydroxyapatite nanoparticles for potential application in bone tumor therapy. J Inorg Biochem. 2021 Feb;215:111334. doi: 10.1016/j.jinorgbio.2020.111334.

Petre D, Leeuwenburgh SCG. The use of fibers in bone tissue engineering. Tissue Eng Part B Rev. 2020 Dec 29. doi: 10.1089/ten.TEB.2020.0252.

Shaheen MY, Basudan AM, Niazy AA, van den Beucken JJJP, Jansen JA, Alghamdi HS. Histological and Histomorphometric Analyses of Bone Regeneration in Osteoporotic Rats Using a Xenograft Material. Materials (Basel). 2021 Jan 5;14(1):E222. doi: 10.3390/ma14010222.

2020

Ning K, Loomans B, Yeung C, Li J, Yang F, Leeuwenburgh S.Influence of microcapsule parameters and initiator concentration on the self-healing capacity of resin-based dental composites. Dent Mater. 2020 Dec 19;S0109-5641(20)30345-6. doi: 10.1016/j.dental.2020.11.025.

van Oirschot BAJA, Jansen JA, van de Ven CJJM, Geven EJW, Gossen JA. Evaluation of Collagen Membranes Coated with Testosterone and Alendronate to Improve Guided Bone Regeneration in Mandibular Bone Defects in Minipigs. J Oral Maxillofac Res. 2020 Nov 30;11(3):e4. doi: 10.5037/jomr.2020.11304.

Zhuang Z, Zhang Y, Sun S, Li Q, Chen K, An C, Wang L, van den Beucken JJJP, Wang H. Control of Matrix Stiffness Using Methacrylate-Gelatin Hydrogels for a Macrophage-Mediated Inflammatory Response. ACS Biomater Sci Eng. 2020 May 11;6(5):3091-3102. doi: 10.1021/acsbiomaterials.0c00295.

Nadar RA, Franssen GM, van Dijk NWM, Codee-van der Schilden K, de Weijert M, Oosterwijk E, Iafisco M, Margiotta N, Heskamp S, van den Beucken JJJP, Leeuwenburgh SCG. Bone tumor-targeted delivery of theranostic 195mPt-bisphosphonate complexes promotes killing of metastatic tumor cells. Mater Today Bio. 2020 Dec 7;9:100088. doi: 10.1016/j.mtbio.2020.100088.

Paknahad A, Goudarzi M, Kucko NW, Leeuwenburgh SCG, Sluys LJ. Calcium phosphate cement reinforced with poly(vinyl alcohol) fibers: An experimental and numerical failure analysis. Acta Biomater. 2020 Oct 24:S1742-7061(20)30603-6. doi: 10.1016/j.actbio.2020.10.014.

Federico S, Pitarresi G, Palumbo FS, Fiorica C, Yang F, Giammona G. Hyaluronan alkyl derivatives-based electrospun membranes for potential guided bone regeneration: Fabrication, characterization and in vitro osteoinductive properties. Colloids Surf B Biointerfaces. 2020 Nov 4;197:111438. doi: 10.1016/j.colsurfb.2020.111438.

Wang B, Booij-Vrieling HE, Bronkhorst EM, Shao J, Kouwer PHJ, Jansen JA, Walboomers XF, Yang F. Antimicrobial and anti-inflammatory thermo-reversible hydrogel for periodontal delivery. Acta Biomater. 2020 Oct 15;116:259-267. doi: 10.1016/j.actbio.2020.09.018.

Basudan AM, Shaheen MY, Niazy AA, van den Beucken JJJP, Jansen JA, Alghamdi HS. Histomorphometric Evaluation of Peri-Implant Bone Response to Intravenous Administration of Zoledronate (Zometa®) in an Osteoporotic Rat Model. Materials (Basel). 2020 Nov 20;13(22):5248. doi: 10.3390/ma13225248.

Torrecilla IL, van den Beucken JJJP, Jansen JA. Calcium Phosphate Cements: Optimization toward Biodegradability. Acta Biomater. 2020 Oct 13:S1742-7061(20)30602-4. doi: 10.1016/j.actbio.2020.10.013.

Guo JL, Kim YS, Orchard E, van den Beucken J, Jansen JA, Wong MEK DDS, Mikos AG. A Rabbit Femoral Condyle Defect Model for Assessment of Osteochondral Tissue Regeneration. Tissue Eng Part C Methods. 2020 Oct 14. doi: 10.1089/ten.TEC.2020.0261.

Shaheen M, Basudan A, Niazy A, van den Beucken J, Jansen JA, Alghamdi H. Impact of single or combined drug therapy on bone regeneration in healthy and osteoporotic rats. Tissue Eng Part A. 2020 Aug 25. doi: 10.1089/ten.TEA.2020.0122.

Op 't Veld RC, Walboomers XF, Jansen JA, Wagener FADTG. Design Considerations for Hydrogel Wound Dressings: Strategic and Molecular Advances. Tissue Eng Part B Rev. 2020 Jun;26(3):230-248. doi: 10.1089/ten.TEB.2019.0281.

Parfenov VA, Mironov VA, van Kampen KA, Karalkin PA, Koudan EV, Pereira FD, Petrov SV, Nezhurina EK, Petrov OF, Myasnikov MI, Walboomers FX, Engelkamp H, Christianen P, Khesuani YD, Moroni L, Mota C. Scaffold-free and label-free biofabrication technology using levitational assembly in a high magnetic field. Biofabrication. 2020 Aug 24;12(4):045022. doi: 10.1088/1758-5090/ab7554.

Ali M, Kucko N, Jansen JA, Yang F, Walboomers XF. The effect of lipoxin A4 on E. coli LPS-induced osteoclastogenesis. Clin Oral Investig. 2020 Jun 6. doi: 10.1007/s00784-020-03385-3.

Genzel L, Adan R, Berns B, van den Beucken JJJP, Blokland A, Boddeke EHWGM, Bogers WM, Bontrop R, Bulthuis R, Bousema T, Clevers H, Coenen TCJJ, van Dam AM, Deen PMT, van Dijk KW, Eggen BJL, Elgersma Y, Erdogan I, Englitz B, Fentener van Vlissingen JM, la Fleur S, Fouchier R, Fitzsimons CP, Frieling W, Haagmans B, Heesters BA, Henckens M, Herfst S, Hol E, van den Hove D, de Jonge MI, Jonkers J, Joosten LAB, Kalsbeek A, Kamermans M, Kampinga HH, Kas MJ, Keijer J, Kersten S, Kiliaan AJ, Kooij TWA, Kooijman S, Koopman W, Korosi A, Krugers HJ, Kuiken T, Kushner S, Langermans JAM, Lesscher H, Lucassen PJ, Lutgens E, Netea MG, Noldus LPJJ, van der Meer JWM, Meye FJ, Mul JD, van Oers K, Olivier JDA, Pasterkamp RJ, Philippens IHCHM, Prickaerts J, Pullox B, Rensen PCN, van Rheenen J, van Rij RP, Ritsma L, Rockx BHG, Roozendaal B, van Schothorst EM, Stittelaar K, Stockhofe N, Swaab DF, de Swart RL, Vanderschuren LJMJ, de Vries T, de Vrij F, van Wezel M, Wierenga CJ, Wiesmann M, Willuhn I, de Zeeuw CI, Homberg JR. How the COVID-19 pandemic highlights the necessity of animal research. Current Biology 2020. https://doi.org/10.1016/j.cub.2020.08.030.

Lodoso-Torrecilla I, Klein Gunnewiek R, Grosfeld EC, de Vries RBM, Habibović P, Jansen JA, van den Beucken JJJP. Bioinorganic supplementation of calcium phosphate-based bone substitutes to improve in vivo performance: a systematic review and meta-analysis of animal studies. Biomater Sci. 2020 Jul 30. doi: 10.1039/d0bm00599a. 

Schickert S, Pinto JC, Jansen J, Leeuwenburgh SCG, van den Beucken JJJP. Tough and injectable fiber reinforced calcium phosphate cement as an alternative to polymethylmethacrylate cement for vertebral augmentation: a biomechanical study. Biomater Sci. 2020 Jun 24. doi: 10.1039/d0bm00413h.

Watson E, Smith BT, Smoak MM, Tatara AM, Shah SR, Pearce HA, Hogan KJ, Shum J, Melville JC, Hanna IA, Demian N, Wenke JC, Bennett GN, van den Beucken JJJP, Jansen JA, Wong ME, Mikos AG. Localized mandibular infection affects remote in vivo bioreactor bone generation. Biomaterials . https://doi.org/10.1016/j.biomaterials.2020.120185.

Nadar RA, Asokan N, Degli Esposti L, Curci A, Barbanente A, Schlatt L, Karst U, Iafisco M, Margiotta N, Brand M, van den Beucken JJJP, Bornhäuser M, Leeuwenburgh SCG. Preclinical evaluation of platinum-loaded hydroxyapatite nanoparticles in an embryonic zebrafish xenograft model. Nanoscale. 2020 Jun 19. doi: 10.1039/d0nr04064a.

Watson E, Tatara AM, van den Beucken J, Jansen JA, Wong MEK DDS, Mikos AG. An Ovine Model of in Vivo Bioreactor-based Bone Generation. Tissue Eng Part C Methods. 2020 Jun 14. doi: 10.1089/ten.TEC.2020.0125.

Holweg P, Berger L, Cihova M, Donohue N, Clement B, Schwarze U, Sommer NG, Hohenberger G, van den Beucken JJJP, Seibert F, Leithner A, Löffler JF, Weinberg AM. A lean magnesium-zinc-calcium alloy ZX00 used for bone fracture stabilization in a large growing-animal model. Acta Biomater. 2020 Jun 14:S1742-7061(20)30334-2. doi: 10.1016/j.actbio.2020.06.013.

Aerts E, Li J, Van Steenbergen MJ, Degrande T, Jansen JA, Walboomers XF. Porous titanium fiber mesh with tailored elasticity and its effect on stromal cells. J Biomed Mater Res B Appl Biomater. 2020 Jul;108(5):2180-2191. doi: 10.1002/jbm.b.34556.

Schickert SL, van den Beucken JJJP, Leeuwenburgh SCG, Jansen JA. Pre-Clinical Evaluation of Biological Bone Substitute Materials for Application in Highly Loaded Skeletal Sites. Biomolecules. 2020 Jun 9;10(6):E883. 10.3390/biom10060883.

Schickert SL, Jansen JA, Bronkhorst EM, van den Beucken JJ, Leeuwenburgh SC. Stabilizing dental implants with a fiber-reinforced calcium phosphate cement: an in vitro and in vivo study. Acta Biomater. 2020 Apr 21. pii: S1742-7061(20)30167-7. doi: 10.1016/j.actbio.2020.03.026.

Boerman MA, Roozen EA, Franssen GM, Bender JCME, Hoogenboom R, Leeuwenburgh SCG, Laverman P, van Hest JCM, van Goor H, Félix Lanao RP. Degradation and excretion of poly (2-oxazoline) based hemostatic materials. Materialia 2020;100763. https://doi.org/10.1016/j.mtla.2020.100763.

Shahbazi MA, Shrestha N, Pierchala MK, Kadumudi FB, Mehrali M, Hasany M, Préat V, Leeuwenburgh S, Dolatshahi-Pirouz A. A self-healable, moldable and bioactive biomaterial gum for personalised and wearable drug delivery. J Mater Chem B. 2020 May 21;8(19):4340-4356. https://doi.org/10.1039/C9TB02156F.

Wang, J. Toebes, B. J. Plachokova, A. S. Liu, Q. Deng, D. Jansen, J. A. Yang, F. Wilson, D. A. Self-Propelled PLGA Micromotor with Chemotactic Response to Inflammation. Adv Healthc Mater. 2020 Apr;9(7):e1901710. 10.1002/adhm.201901710.

Wang, B. Wang, J. Shao, J. Kouwer, P. H. J. Bronkhorst, E. M. Jansen, J. A. Walboomers, X. F. Yang, F. A tunable and injectable local drug delivery system for personalized periodontal application. J Control Release. 2020 May 5;324:134-145. 10.1016/j.jconrel.2020.05.004.

NW Kucko, DG Petre, M de Ruiter, RP Herber, CG Leeuwenburgh. Micro-and macromechanical characterization of the influence of surface-modification of poly (vinyl alcohol) fibers on the reinforcement of calcium phosphate cements. J Mech Behav Biomed Mater;2020;103776. https://doi.org/10.1016/j.jmbbm.2020.103776.

Umuhoza D, Yang F, Long D, Hao Z, Dai J, Zhao A. Strategies for Tuning the Biodegradation of Silk Fibroin-Based Materials for Tissue Engineering Applications. ACS Biomater Sci Eng 2020, 6 (3), 1290-1310. 10.1021/acsbiomaterials.9b01781.

Kapat K, Shubhra QTH, Zhou M, Leeuwenburgh SCG. Piezoelectric Nano‐Biomaterials for Biomedicine and Tissue Regeneration. Adv Funct Mater 2020, 1909045. https://doi.org/10.1002/adfm.201909045.

Cheng X, Deng D, Chen L, Jansen JA, Leeuwenburgh SCG, Yang F. Electrodeposited Assembly of Additive-Free Silk Fibroin Coating from Pre-Assembled Nanospheres for Drug Delivery. ACS Appl Mater Interfaces. 2020 Feb 25. doi: 10.1021/acsami.9b21808.

Paknahad A, Kucko NW, Leeuwenburgh SCG, Sluys LJ. Experimental and numerical analysis on bending and tensile failure behavior of calcium phosphate cements. J Mech Behav Biomed Mater. 2020 Mar;103:103565. doi: 10.1016/j.jmbbm.2019.103565.

Barbanente A, Nadar R, Degli Esposti L, Palazzo B, Iafisco M, van den Beucken JJJP, Leeuwenburgh SCG, Margiotta N. Platinum-loaded, selenium-doped hydroxyapatite nanoparticles selectively reduce proliferation of prostate and breast cancer cells co-cultured in the presence of stem cells. J Mater Chem B. 2020 https://doi.org/10.1039/D0TB00390E.

Nadar RA, Farbod K, Codee-van der Schilden K, Schlatt L, Crone B, Asokan N, Curci A, Bohaneausar, Iafisco M, Margiotta N, Karst U, Heskamp S, Boerman OC, van den Beucken JJJP, Leeuwenburgh SCG. Targeting of radioactive platinum-bisphosphonate anticancer drugs to bone of high metabolic activity. Sci Rep. 2020 doi: 10.1038/s41598-020-62039-2.

Li J, Jansen JA, Walboomers XF, van den Beucken JJ. Mechanical aspects of dental implants and osseointegration: A narrative review. J Mech Behav Biomed Mater. 2020 Mar;103:103574. doi: 10.1016/j.jmbbm.2019.103574. 

Ali M, Yang F, Jansen JA, Walboomers XF. Lipoxin suppresses inflammation via the TLR4/MyD88/NF-Œ∫B pathway in periodontal ligament cells. Oral Dis. 2020, 26 (2), 429-438. doi: 10.1111/odi.13250.

Lodoso-Torrecilla I, Stumpel F, Jansen JA, van den Beucken JJJP. Early-stage macroporosity enhancement in calcium phosphate cements by inclusion of poly(N-vinylpyrrolidone) particles as a porogen. Materials Today Communications 23 (2020): 100901. https://doi.org/10.1016/j.mtcomm.2020.100901

Habibovic P, Hofmann S, van den Beucken J. 29th annual conference of the European Society for Biomaterials. Biomater Sci. 2020 Jan 1 https://doi: 10.1039/c9bm90066g.

Orive G, Taebnia N, Dolatshahi-Pirouz A. A New Era for Cyborg Science Is Emerging: The Promise of Cyborganic Beings. Adv Healthc Mater. 2020 Jan 9(1):e1901023. doi: 10.1002/adhm.201901023.

Darouie S, Ansari Majd S, Rahimi F, Hashemi E, Kabirsalmani M, Dolatshahi-Pirouz A, Arpanaei A. The fate of mesenchymal stem cells is greatly influenced by the surface chemistry of silica nanoparticles in 3D hydrogel-based culture systems. Mater Sci Eng C Mater Biol Appl. 2020 Jan 106:110259. doi: 10.1016/j.msec.2019.110259.

2019

Op 't Veld RC, Eerden M, Wagener FADTG, Kouwer PHJ, Jansen JA, Walboomers XF. Polyisocyanopeptide hydrogels are effectively sterilized using supercritical carbon dioxide. Tissue Eng Part C Methods. 2019 Dec 18. doi: 10.1089/ten.TEC.2019.0305.

Ali M, Yang F, Jansen JA, Walboomers XF. Lipoxin suppresses inflammation via the TLR4/MyD88/NF-Œ∫B pathway in periodontal ligament cells. Oral Dis. 2019 Dec 9. doi: 10.1111/odi.13250.

Grosfeld EC, Smith B, Santoro M, Lodoso-Torrecilla I, Jansen JA, Ulrich D, Melchiorri AJ, Scott DW, Mikos AG, van den Beucken JJ. Fast dissolving glucose porogens for early calcium phosphate cement degradation and bone regeneration. Biomed Mater. 2019 Dec 6. doi: 10.1088/1748-605X/ab5f9c.

Wang B, Mastrogiacomo S, Yang F, Shao J, Ong MMA, Chanchareonsook N, Jansen JA, Walboomers XF, Yu N. Application of BMP-Bone Cement and FGF-Gel on Periodontal Tissue Regeneration in Nonhuman Primates. Tissue Eng Part C Methods. 2019 25(12):748-756. doi: 10.1089/ten.TEC.2019.0160.

Alshehri F, Alshehri M, Sumague T, Niazy A, Jansen J, van den Beucken J, Alghamdi H. Evaluation of Peri-Implant Bone Grafting Around Surface-Porous Dental Implants: An In Vivo Study in a Goat Model. Materials (Basel). 2019 Nov 3 12(21). pii: E3606. doi: 10.3390/ma12213606.

de Avila ED, van Oirschot BA, van den Beucken JJJP. Biomaterial-based possibilities for managing peri-implantitis. J Periodontal Res. 2019 Oct 22. [Epub ahead of print] Review. doi: 10.1111/jre.12707.

Wang B, Shao J, Fu J, Jansen JA, Walboomers XF, Hooijmans CR, Van Luijk J, Yang F. Topical Host-Modulating Therapy for Periodontal Regeneration: A Systematic Review and Meta-Analysis. Tissue Eng Part B Rev. 2019 Dec 25(6):526-543. doi: 10.1089/ten.TEB.2019.0184.

Gungordu HI, Bao M, van Helvert S, Jansen JA, Leeuwenburgh SCG, Walboomers XF. Effect of mechanical loading and substrate elasticity on the osteogenic and adipogenic differentiation of mesenchymal stem cells. J Tissue Eng Regen Med. 2019 Dec 13(12):2279-2290. doi: 10.1002/term.2956.

Talebian S, Mehrali M, Taebnia N, Pennisi CP, Kadumudi FB, Foroughi J, Hasany M, Nikkhah M, Akbari M, Orive G, Dolatshahi-Pirouz A. Self-Healing Hydrogels: The Next Paradigm Shift in Tissue Engineering? Adv Sci (Weinh). 2019 Jun 14 6(16):1801664. doi: 10.1002/advs.201801664.

Orive G, Echave MC, Pedraz JL, Golafshan N, Dolatshahi-Pirouz A, Paolone G, Emerich D. Advances in cell-laden hydrogels for delivering therapeutics. Expert Opin Biol Ther. 2019 Dec 19(12):1219-1222. doi: 10.1080/14712598.2019.1654452.

Shaheen MY, Basudan AM, de Vries RB, van den Beucken JJJP, Jansen JA, Alghamdi HS. Bone Regeneration Using Antiosteoporotic Drugs in Adjunction with Bone Grafting: A Meta-Analysis. Tissue Eng Part B Rev. 2019 Dec 25(6):500-509. doi: 10.1089/ten.TEB.2019.0132.

Yan XZ, van den Beucken JJJP, Yuan C, Jansen JA, Yang F. Evaluation of polydimethylsiloxane-based substrates for in vitro culture of human periodontal ligament cells. J Biomed Mater Res A. 2019 Dec 107(12):2796-2805. doi: 10.1002/jbm.a.36782.

Sanchez-Fernandez MJ, Immers MR, Felix Lanao RP, Yang F, Bender JCME, Mecinoviƒá J, Leeuwenburgh SCG, van Hest JCM. Alendronate-Functionalized Poly(2-oxazoline)s with Tunable Affinity for Calcium Cations. Biomacromolecules. 2019 Aug 12 20(8):2913-2921. doi: 10.1021/acs.biomac.9b00104.

Hasany M, Taebnia N, Yaghmaei S, Shahbazi MA, Mehrali M, Dolatshahi-Pirouz A, Arpanaei A. Silica nanoparticle surface chemistry: An important trait affecting cellular biocompatibility in two and three dimensional culture systems. Colloids Surf B Biointerfaces. 2019 Oct 1 182:110353. doi: 10.1016/j.colsurfb.2019.110353.

Lukin I, Musquiz S, Erezuma I, Al-Tel TH, Golafshan N, Dolatshahi-Pirouz A, Orive G. Can 4D bioprinting revolutionize drug development? Expert Opin Drug Discov. 2019 Oct 14(10):953-956. doi: 10.1080/17460441.2019.1636781.

Paknahad A, Petre DG, Leeuwenburgh SCG, Sluys LJ. Interfacial characterization of poly (vinyl alcohol) fibers embedded in a calcium phosphate cement matrix: An experimental and numerical investigation. Acta Biomater. 2019 Sep 15 96:582-593. doi: 10.1016/j.actbio.2019.06.044.

Petre DG, Nadar R, Tu Y, Paknahad A, Wilson DA, Leeuwenburgh SCG. Thermoresponsive Brushes Facilitate Effective Reinforcement of Calcium Phosphate Cements. ACS Appl Mater Interfaces. 2019 Jul 31 11(30):26690-26703. doi: 10.1021/acsami.9b08311.

Dinoro J, Maher M, Talebian S, Jafarkhani M, Mehrali M, Orive G, Foroughi J, Lord MS, Dolatshahi-Pirouz A. Sulfated polysaccharide-based scaffolds for orthopaedic tissue engineering. Biomaterials. 2019 Sep 214:119214. doi: 10.1016/j.biomaterials.2019.05.025.

Araujo-Gomes N, Romero-Gavil√°n F, Zhang Y, Martinez-Ramos C, Elortza F, Azkargorta M, Martin de Llano JJ, Gurruchaga M, Go√±i I, van den Beucken JJJP, Suay J. Complement proteins regulating macrophage polarisation on biomaterials. Colloids Surf B Biointerfaces. 2019 Sep 1 181:125-133. doi: 10.1016/j.colsurfb.2019.05.039

Op 't Veld RC, Joosten L, van den Boomen OI, Boerman OC, Kouwer P, Middelkoop E, Rowan AE, Jansen JA, Walboomers XF, Wagener FADTG. Monitoring (111)In-labelled polyisocyanopeptide (PIC) hydrogel wound dressings in full-thickness wounds. Biomater Sci. 2019 Jul 1 7(7):3041-3050. doi: 10.1039/c9bm00661c.

Crone B, Schlatt L, Nadar RA, van Dijk NWM, Margiotta N, Sperling M, Leeuwenburgh S, Karst U. Quantitative imaging of platinum-based antitumor complexes in bone tissue samples using LA-ICP-MS. J Trace Elem Med Biol. 2019 Jul 54:98-102. doi: 10.1016/j.jtemb.2019.04.011.

Wang J, Jansen JA, Yang F. Electrospraying: Possibilities and Challenges of Engineering Carriers for Biomedical Applications-A Mini Review. Front Chem. 2019 Apr 25;7:258. doi: 10.3389/fchem.2019.00258.

Echave MC, Hern√°ez-Moya R, Iturriaga L, Pedraz JL, Lakshminarayanan R, Dolatshahi-Pirouz A, Taebnia N, Orive G. Recent advances in gelatin-based therapeutics. Expert Opin Biol Ther. 2019 Aug 19(8):773-779. doi: 10.1080/14712598.2019.1610383.

Jin S, Sun F, Zou Q, Huang J, Zuo Y, Li Y, Wang S, Cheng L, Man Y, Yang F, Li J. Fish Collagen and Hydroxyapatite Reinforced Poly(lactide- co-glycolide) Fibrous Membrane for Guided Bone Regeneration. Biomacromolecules. 2019 May 13;20(5):2058-2067. doi: 10.1021/acs.biomac.9b00267.

Mastrogiacomo S, Dou W, Jansen JA, Walboomers XF. Magnetic Resonance Imaging of Hard Tissues and Hard Tissue Engineered Bio-substitutes. Mol Imaging Biol. 2019 Dec 21(6):1003-1019. doi: 10.1007/s11307-019-01345-2.

Wang J, Helder L, Shao J, Jansen JA, Yang M, Yang F. Encapsulation and release of doxycycline from electrospray-generated PLGA microspheres: Effect of polymer end groups. Int J Pharm. 2019 Jun 10;564:1-9. doi: 10.1016/j.ijpharm.2019.04.023.

Celikkin N, Mastrogiacomo S, Walboomers XF, Swieszkowski W. Enhancing X-ray Attenuation of 3D Printed Gelatin Methacrylate (GelMA) Hydrogels Utilizing Gold Nanoparticles for Bone Tissue Engineering Applications. Polymers (Basel). 2019 Feb 20 11(2). pii: E367. doi: 10.3390/polym11020367.

Lodoso-Torrecilla I, Grosfeld EC, Marra A, Smith BT, Mikos AG, Ulrich DJ, Jansen JA, van den Beucken JJ. Multimodal porogen platforms for calcium phosphate cement degradation. J Biomed Mater Res A. 2019 Aug 107(8):1713-1722. doi: 10.1002/jbm.a.36686.

Kadumudi FB, Jahanshahi M, Mehrali M, Zsurzsan TG, Taebnia N, Hasany M, Mohanty S, Knott A, Godau B, Akbari M, Dolatshahi-Pirouz A. A Protein-Based, Water-Insoluble, and Bendable Polymer with Ionic Conductivity: A Roadmap for Flexible and Green Electronics. Adv Sci (Weinh). 2019 Jan 9 6(5):1801241. doi: 10.1002/advs.201801241.

Tatara AM, Koons GL, Watson E, Piepergerdes TC, Shah SR, Smith BT, Shum J, Melville JC, Hanna IA, Demian N, Ho T, Ratcliffe A, van den Beucken JJJP, Jansen JA, Wong ME, Mikos AG. Biomaterials-aided mandibular reconstruction using in vivo bioreactors. Proc Natl Acad Sci U S A. 2019 Apr 2 116(14):6954-6963. doi: 10.1073/pnas.1819246116.

Mehrali M, Thakur A, Kadumudi FB, Pierchala MK, Cordova JAV, Shahbazi MA, Mehrali M, Pennisi CP, Orive G, Gaharwar AK, Dolatshahi-Pirouz A. Pectin Methacrylate (PEMA) and Gelatin-Based Hydrogels for Cell Delivery: Converting Waste Materials into Biomaterials. ACS Appl Mater Interfaces. 2019 Apr 3 11(13):12283-12297. doi: 10.1021/acsami.9b00154.

Echave MC, Pimenta-Lopes C, Pedraz JL, Mehrali M, Dolatshahi-Pirouz A, Ventura F, Orive G. Enzymatic crosslinked gelatin 3D scaffolds for bone tissue engineering. Int J Pharm. 2019 May 1 562:151-161. doi: 10.1016/j.ijpharm.2019.02.043.

Serôdio R, Schickert SL, Costa-Pinto AR, Dias JR, Granja PL, Yang F, Oliveira AL. Ultrasound sonication prior to electrospinning tailors silk fibroin/PEO membranes for periodontal regeneration. Mater Sci Eng C Mater Biol Appl. 2019 May;98:969-981. doi: 10.1016/j.msec.2019.01.055.

Shao J, Wang B, Li J, Jansen JA, Walboomers XF, Yang F. Antibacterial effect and wound healing ability of silver nanoparticles incorporation into chitosan-based nanofibrous membranes. Mater Sci Eng C Mater Biol Appl. 2019 May 98:1053-1063. doi: 10.1016/j.msec.2019.01.073.

Tang H, Husch JFA, Zhang Y, Jansen JA, Yang F, van den Beucken JJJP. Coculture with monocytes/macrophages modulates osteogenic differentiation of adipose-derived mesenchymal stromal cells on poly(lactic-co-glycolic) acid/polycaprolactone scaffolds. J Tissue Eng Regen Med. 2019 May 13(5):785-798. doi: 10.1002/term.2826.

Carrow JK, Di Luca A, Dolatshahi-Pirouz A, Moroni L, Gaharwar AK. 3D-printed bioactive scaffolds from nanosilicates and PEOT/PBT for bone tissue engineering. Regen Biomater. 2019 Feb 6(1):29-37. doi: 10.1093/rb/rby024.

Kucko NW, Li W, Garc√≠a Martinez MA, Rehman IU, Ulset AT, Christensen BE, Leeuwenburgh SCG, Herber RP. Sterilization effects on the handling and degradation properties of calcium phosphate cements containing poly ((D,L) -lactic-co-glycolic acid) porogens and carboxymethyl cellulose. J Biomed Mater Res B Appl Biomater. 2019 Oct 107(7):2216-2228. doi: 10.1002/jbm.b.34306.

Zhang Y, Cheng X, Jansen JA, Yang F, van den Beucken JJJP. Titanium surfaces characteristics modulate macrophage polarization. Mater Sci Eng C Mater Biol Appl. 2019 Feb 1 95:143-151. doi: 10.1016/j.msec.2018.10.065.

Shao J, Ma J, Lin L, Wang B, Jansen JA, Walboomers XF, Zuo Y, Yang F. Three-Dimensional Printing of Drug-Loaded Scaffolds for Antibacterial and Analgesic Applications. Tissue Eng Part C Methods. 2019 Apr 25(4):222-231. doi: 10.1089/ten.TEC.2018.0293.

Zhang Y, Yang W, Devit A, van den Beucken JJJP. Efficiency of coculture with angiogenic cells or physiological BMP-2 administration on improving osteogenic differentiation and bone formation of MSCs. J Biomed Mater Res A. 2019 Mar 107(3):643-653. doi: 10.1002/jbm.a.36581

Petre DG, Kucko NW, Abbadessa A, Vermonden T, Polini A, Leeuwenburgh SCG. Surface functionalization of polylactic acid fibers with alendronate groups does not improve the mechanical properties of fiber-reinforced calcium phosphate cements. J Mech Behav Biomed Mater. 2019 Feb 90:472-483. doi: 10.1016/j.jmbbm.2018.11.003.

Wang B, Shao J, Jansen JA, Walboomers XF, Yang F. A Novel Thermoresponsive Gel as a Potential Delivery System for Lipoxin. J Dent Res. 2019 Mar 98(3):355-362. doi: 10.1177/0022034518810213.

Orive G, Santos-Vizcaino E, Pedraz JL, Hernandez RM, Vela Ramirez JE, Dolatshahi-Pirouz A, Khademhosseini A, Peppas NA, Emerich DF. 3D cell-laden polymers to release bioactive products in the eye. Prog Retin Eye Res. 2019 Jan 68:67-82. doi: 10.1016/j.preteyeres.2018.10.002.

Basudan AM, Shaheen MY, de Vries RB, van den Beucken JJJP, Jansen JA, Alghamdi HS. Antiosteoporotic Drugs to Promote Bone Regeneration Related to Titanium Implants: A Systematic Review and Meta-Analysis. Tissue Eng Part B Rev. 2019 Apr 25(2):89-99. doi: 10.1089/ten.TEB.2018.0120.

Smith BT, Grosfeld EC, Watson E, Bittner SM, van den Beucken JJJP, Jansen JA, Melchiorri AJ, Wong ME, Mikos AG. Using Fast Dissolving Porogens for Accelerated Bone Regeneration. J Am Coll Surg. 2019 Oct 229(4):E161-162(s2). doi: 10.1016/j.jamcollsurg.2019.08.1169

de Avila ED, Castro AGB, Tagit O, Krom BP, Lowik D, van Well AA, Bannenberg LJ, Vergani CE, van den Beucken JJJP. Anti-bacterial efficacy via drug-delivery system from layer-by-layer coating for percutaneous dental implant components. Appl Surf Sci. 2019 Sep 15 488:194-204. doi: 10.1016/j.apsusc.2019.05.154.

Diba M, Camargo WA, Zinkevich T, Grunewald A, Detsch, R, Kabiri, Y, Kentgens APM, Boccaccini AR, van den Beucken JJJP, Leeuwenburgh SCG. Hybrid particles derived from alendronate and bioactive glass for treatment of osteoporotic bone defects. J Mater Chem B. 2019 Feb 7 7(5):796-808. doi: 10.1039/c8tb03062f.

Ali M, Walboomers XF, Jansen JA, Yang F. Influence of formulation parameters on encapsulation of doxycycline in PLGA microspheres prepared by double emulsion technique for the treatment of periodontitis. Journal of Drug Delivery Science and Technology. 2019;52:263-71. doi: 10.1016/j.jddst.2019.04.031.

Cheng X, Yang F. More Than Just a Barrier-Challenges in the Development of Guided Bone Regeneration Membranes. Matter. 2019;1(3):558-60. doi: 10.1016/j.matt.2019.08.009.

Lin LL, Shao JL, Ma JQ, Zou Q, Li JD, Zuo Y, Yang F, Li Y. Development of ciprofloxacin and nano-hydroxyapatite dual-loaded polyurethane scaffolds for simultaneous treatment of bone defects and osteomyelitis. Materials Letters. 2019;253:86-9. doi: 10.1016/j.matlet.2019.06.028.

Kucko NW, de Lacerda Schickert S, Marques TS, Herber RP, van den Beucken JJJP, Zuo Y, Leeuwenburgh SCG. Tough and Osteocompatible Calcium Phosphate Cements Reinforced with Poly(vinyl alcohol) Fibers. ACS Biomat Sci Eng. 2019 5(5):2491-2505. doi: 10.1021/acsbiomaterials.9b00226.

Sanchez-Fernandez MJ, Hammoudeh H, Felix Lanao RP, van Erk M, van Hest JCM, Leeuwenburgh SCG. Bone-Adhesive Materials: Clinical Requirements, Mechanisms of Action, and Future Perspective. Adv Mater Interfaces 2019 6(4):1802021. doi: 10.1002/admi.201802021.

Zhang Y, Grosfeld EC, Camargo WA, Tang H, Magri AMP, van den Beucken JJJP. Efficacy of intraoperatively prepared cell-based constructs for bone regeneration. Stem Cell Res Ther. 2018 Oct 25 25;9(1):283. doi: 10.1186/s13287-018-1026-7.

2018

Sa Y, Yang F, Wang Y, Wolke JGC, Jansen JA. Modifications of Poly(Methyl Methacrylate) Cement for Application in Orthopedic Surgery. Adv Exp Med Biol. 2018;1078:119-134. doi: 10.1007/978-981-13-0950-2_7.

Mehrali M, Bagherifard S, Akbari M, Thakur A, Mirani B, Mehrali M, Hasany M, Orive G, Das P, Emneus J, Andresen TL, Dolatshahi-Pirouz A. Blending Electronics with the Human Body: A Pathway toward a Cybernetic Future. Adv Sci (Weinh). 2018 Aug 1 5(10):1700931. doi: 10.1002/advs.201700931.

Shao J, Wang B, Bartels CJM, Bronkhorst EM, Jansen JA, Walboomers XF, Yang F. Chitosan-based sleeves loaded with silver and chlorhexidine in a percutaneous rabbit tibia model with a repeated bacterial challenge. Acta Biomater. 2018 Dec 82:102-110. doi: 10.1016/j.actbio.2018.10.021.

van Houdt CIA, Gabbai-Armelin PR, Lopez-Perez PM, Ulrich DJO, Jansen JA, Renno ACM, van den Beucken JJJP. Alendronate release from calcium phosphate cement for bone regeneration in osteoporotic conditions. Sci Rep. 2018 Oct 18 8(1):15398. doi: 10.1038/s41598-018-33692-5.

Zhang Y, Chen SE, Shao J, van den Beucken JJJP. Combinatorial Surface Roughness Effects on Osteoclastogenesis and Osteogenesis. ACS Appl Mater Interfaces. 2018 Oct 31 10(43):36652-36663. doi: 10.1021/acsami.8b10992.

Zhang X, Song J, Klymov A, Zhang Y, de Boer L, Jansen JA, van den Beucken JJ, Yang F, Zaat SA, Leeuwenburgh SC. Monitoring local delivery of vancomycin from gelatin nanospheres in zebrafish larvae. Int J Nanomedicine. 2018 Sep 13 13:5377-5394. doi: 10.2147/IJN.S168959.

Hasany M, Thakur A, Taebnia N, Kadumudi FB, Shahbazi MA, Pierchala MK, Mohanty S, Orive G, Andresen TL, Foldager CB, Yaghmaei S, Arpanaei A, Gaharwar AK, Mehrali M, Dolatshahi-Pirouz A. Combinatorial Screening of Nanoclay-Reinforced Hydrogels: A Glimpse of the "Holy Grail" in Orthopedic Stem Cell Therapy? ACS Appl Mater Interfaces. 2018 Oct 17 10(41):34924-34941. doi: 10.1021/acsami.8b11436.

Diba M, Polini A, Petre DG, Zhang Y, Leeuwenburgh SCG. Fiber-reinforced colloidal gels as injectable and moldable biomaterials for regenerative medicine. Mater Sci Eng C Mater Biol Appl. 2018 Nov 1 92:143-150. doi: 10.1016/j.msec.2018.06.038.

Jin S, Li J, Wang J, Jiang J, Zuo Y, Li Y, Yang F. Electrospun silver ion-loaded calcium phosphate/chitosan antibacterial composite fibrous membranes for guided bone regeneration. Int J Nanomedicine. 2018 Aug 10;13:4591-4605. doi: 10.2147/IJN.S167793.

Mastrogiacomo S, Kownacka AE, Dou W, Burke BP, de Rosales RTM, Heerschap A, Jansen JA, Archibald SJ, Walboomers XF. Bisphosphonate Functionalized Gadolinium Oxide Nanoparticles Allow Long-Term MRI/CT Multimodal Imaging of Calcium Phosphate Bone Cement. Adv Healthc Mater. 2018 Oct 7(19):e1800202. doi: 10.1002/adhm.201800202.

Smith BT, Lu A, Watson E, Santoro M, Melchiorri AJ, Grosfeld EC, van den Beucken JJJP, Jansen JA, Scott DW, Fisher JP, Mikos AG. Incorporation of fast dissolving glucose porogens and poly(lactic-co-glycolic acid) microparticles within calcium phosphate cements for bone tissue regeneration. Acta Biomater. 2018 Sep 15 78:341-350. doi: 10.1016/j.actbio.2018.07.054.

Grün NG, Holweg P, Tangl S, Eichler J, Berger L, van den Beucken JJJP, L√∂ffler JF, Klestil T, Weinberg AM. Comparison of a resorbable magnesium implant in small and large growing-animal models. Acta Biomater. 2018 Sep 15 78:378-386. doi: 10.1016/j.actbio.2018.07.044.

Iturriaga L, Hernandez-Moya R, Erezuma I, Dolatshahi-Pirouz A, Orive G. Advances in stem cell therapy for cartilage regeneration in osteoarthritis. Expert Opin Biol Ther. 2018 Aug 18(8):883-896. doi: 10.1080/14712598.2018.1502266.

Cai X, Yang F, Walboomers XF, Wang Y, Jansen JA, van den Beucken JJJP, Plachokova AS. Periodontal regeneration via chemoattractive constructs. J Clin Periodontol. 2018 Jul 45(7):851-860. doi: 10.1111/jcpe.12928.

Talebian S, Foroughi J, Wade SJ, Vine KL, Dolatshahi-Pirouz A, Mehrali M, Conde J, Wallace GG. Biopolymers for Antitumor Implantable Drug Delivery Systems: Recent Advances and Future Outlook. Adv Mater. 2018 Aug 30(31):e1706665. doi: 10.1002/adma.201706665

Zhang Y, Husch JFA, van den Beucken JJJP. Intraoperative Construct Preparation: A Practical Route for Cell-Based Bone Regeneration. Tissue Eng Part B Rev. 2018 Oct 24(5):403-417. doi: 10.1089/ten.TEB.2018.0010.

Behzadi F, Darouie S, Alavi SM, Shariati P, Singh G, Dolatshahi-Pirouz A, Arpanaei A. Stability and Antimicrobial Activity of Nisin-Loaded Mesoporous Silica Nanoparticles: A Game-Changer in the War against Maleficent Microbes. J Agric Food Chem. 2018 Apr 25 66(16):4233-4243. doi: 10.1021/acs.jafc.7b05492.

Yan XZ, van den Beucken J, Yuan C, Jansen JA, Yang F. Spheroid formation and stemness preservation of human periodontal ligament cells on chitosan films. Oral Dis. 2018 Sep 24(6):1083-1092. doi: 10.1111/odi.12855.

Castro AGB, Diba M, Kersten M, Jansen JA, van den Beucken JJJP, Yang F. Development of a PCL-silica nanoparticles composite membrane for Guided Bone Regeneration. Mater Sci Eng C Mater Biol Appl. 2018 Apr 1;85:154-161. doi: 10.1016/j.msec.2017.12.023.

Castro AGB, Löwik DWPM, van Steenbergen MJ, Jansen JA, van den Beucken JJJP, Yang F. Incorporation of simvastatin in PLLA membranes for guided bone regeneration: effect of thermal treatment on simvastatin release. RSC Advances. 2018 8(50):28546-54 doi: 10.1039/c8ra04397c

Diba M, Spaans S, Ning K, Ippel BD, Yang F, Loomans B, Dankers PYW, Leeuwenburgh SCG. Self-Healing Biomaterials: From Molecular Concepts to Clinical Applications. Adv Mater Interfaces 2018, 5 (17). doi: 10.1002/admi.201800118

Leeuwenburgh SCG, de Belie N, van der Zwaag S. Self-Healing Materials are Coming of Age. Adv Mater Interfaces 2018 5(17): 1800736. doi: 10.1002/admi.201800736​

Versteegden LR, Sloff M, Hoogenkamp HR, Pot MW, Pang J, Hafmans TG, Smit TH, Leeuwenburgh SCG, Oosterwijk E, Feitz WF, Daamen WF, van Kuppevelt TH. A salt-based method to adapt stiffness and biodegradability of porous collagen scaffolds. RSC Advances. 2018 9(63):36742-36750. doi: 10.1039/c9ra06651a.